Toxicity and local anesthetic activity of diterpenoid alkaloids

Abstract

The toxicity and local anesthetic activity of 74 diterpenoid alkaloids differing in the nature and position of functional groups in lycoctonine, heteratisine, napelline, hetisane, atisane, and denudatine skeletons and their synthetic derivatives were investigated. Compounds with local anesthetic activity and duration of action surpassing that of cocaine for surface anesthesia and that of novocaine and lidocaine for infiltration and trunk administration were identified. Structural factors affecting the toxicity and local anesthetic activity of the studied compounds were discussed. © 2007 Springer Science+Business Media, Inc.