Structure elucidation of meroterpenoid habiterpenol, a novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, produced by Phytohabitans suffuscus 3787-5

Abstract

A novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, habiterpenol (1), was isolated from the culture broth of Phytohabitans suffuscus 3787-5. The planar structure of 1 was elucidated by spectroscopic study (1D and 2D NMR, MS, UV and IR), and the relative stereochemistry was elucidated by ROESY experiments. Compound 1 belongs to a pentacyclic meroterpenoid having a labdan-type diterpene connecting to an indane moiety.