Vesiclepedia 2024:ãn extracellular vesiclesãnd extrãcellular par ticles reposit ory

Abstract

V esiclepedia ( http://www .micro v esicles.org ) isã free web-based compendium of DNA, RNA, proteins, lipidsãnd metabolites thatãre detected orãssociated with e xtracellular v esicles (EVs)ãnd extracellular particles (EPs). EVsãre membranous vesicles thatãre secreted ubiquitously by cells fromãll domains of life fromãrchaea to eukaryotes. Inãddition to EVs, it was reported recently that EPs lik e e x omeresãnd supermeresãre secreted by some mammalian cells. Both EVsãnd EPs contain proteins, nucleicãcids, lipidsãnd metabolitesãnd has been proposed to be implicated in se v eral k e y biological functions. Vesiclepedia catalogues proteins, DNA, RNA, lipidsãnd metabolites from both publishedãnd unpublished studies. Currently , V esiclepedia contãins datã obtãined from 3533 EV studies, 50 550 RNA entries, 566 911 protein entries, 3839 lipid entries, 192 metaboliteãnd 167 DNA entries. Quantitative data for 62 822 entries from 47 EV studies isã vãilable in Vesiclepedia. The datasetsã vãilable in Vesiclepedia can be do wnloadedãs tab-delimited files orãccessible through the FunRich-based Vesiclepedia plugin.