Diastolic function and creatine phosphate: An echocardiographic study

Abstract

In primary ischemia or situations in which the heart is forced to operate in a state of relative anaerobiosis, diastolic dysfunction may be the first alteration to appear. Acute infusion of creatine phosphate (5 gm intravenously) in 20 men suffering from chronic ischemic cardiopathy induced a general improvement in the echo-Doppler diastolic function parameters. A statistically significant modification was observed in the parameters that represent the progress of the first part of the diastolic phase: the isovolumetric relaxation time and the protodiastolic deceleration slope rate. These data suggest that creatine phosphate can be usefully employed in cases of serious acute coronary insufficiency or in conditions in which there is a clear but reversible alteration in diastolic function, which if not corrected, threatens to jeopardize the already defective myocardial blood supply as well as the pump function. © 1993 Excerpta Medica, Inc. All rights reserved.