Abstract
In this review we discuss ten promising biological targets of interest for treating type 2 diabetes mellitus, obesity and metabolic syndrome. Namely, we address current experimental and clinical data on several new compounds that affect SGLT2, 11b-HSD1, PTP1B, SCD1, Il-1β, fructose-1,6-bisphosphatase, glycogen phosphorylase, SIRT1, DGAT-1 and GPR119. The body of data shows potential of these substances to become effective antidiabetic agents.
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Tiurenkov, I. N., Kurkin, D. V., Volotova, E. V., Bakulin, D. A., & Lomkina, E. M. (2015). Drug discovery for type 2 diabetes mellitus and metabolic syndrome: Ten novel biological targets. Diabetes Mellitus, 18(1), 101–109. https://doi.org/10.14341/DM20151101-109
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