The prevalence of components of metabolic syndrome in the patients with diabetes melitus type 2 and MODY diabetes in young people of Novosibirsk

Abstract

Aim. To estimate the prevalence of type 2 diabetes mellitus (DM2) and MODY diabetes as well as the prevalence of metabolic syndrome (MS) components for these types of diabetes in the young population of the city of Novosibirsk. Materials and methods. In 2013-2017 years a population survey was conducted of a random representative sample of the population of 25-45 years of both sexes, residents of one of the typical districts of Novosibirsk. WHO criteria (1999-2013) were used for the diagnosis of diabetes: Fasting blood glucose ≥7.0 mmol / l after an 8-hour fasting. Also group with DM2 included persons with a fasting blood glucose level <7.0 mmol / l at the time of the research but they indicated that have DM2 and received a hypoglycemic therapy according to the disease. All patients had a clinical examination including measurement of anthropometric parameters, blood pressure, determination of the lipid spectrum in biochemical blood analysis. Molecular genetic research was performed for patients with debut diabetes at the age of 25-45 years and with phenotypic signs of monogenic forms of diabetes (MODY diabetes) in 2014-2017 years. Results and discussion. The prevalence of DM2 was 2.4% among the residents of 25-45 years old in the city of Novosibirsk (n = 32), it was higher among men (3.4%, n = 21), than among women (1.5%, n = 11, p = 0.02) according to the population screening data for 2013-2017. The prevalence of abdominal obesity (AO) was 50%, hypertriglyceridemia (HTG) 35%, arterial hypertension (AH) 70% in the DM2 group. The prevalence of MODY diabetes was 33.3% among patients with a debut of the disease of 25-45 years and phenotypic signs of this nosology. HTG is defined in 31.6% of patients with MODY diabetes; AH - in 31.6%. The conclusion. 2.2% of patients had DM2 among the adult population of Novosibirsk (25-45 years) in 2013-2017. The prevalence of MS components such as AH, AO and HTG is significantly higher in persons with diabetes than in the population sample without DM. Every third patient aged 25-44 years with diabetes "not of the first type" had MODY diabetes in 2014-2017. The prevalence of HTG is comparable among young patients with DM2 and MODY.