Comparative analysis of activity of cytochrome isoenzyme P450 CYP2C9 in elderly and senile patients and with that in healthy volunteers of the first period of middle age

Abstract

At the first phase of the research the evaluation of the activity of cytochrome CYP2C9 in 18 elderly and geriatric patients was carried out, mean age of the patients was 71.6±9.6 years. At the second phase the efficiency and safety of losartan trial in 18 healthy volunteers of the first period of mature age 26.3±3.5 years was evaluated. To evaluate the activity of isoenzyme of cytochrome P450 CYP2C9 the determination of the concentration of active metabolite of Losartan E-3174 in the urine to the concentration of losartan was used. The concentration ratio E-3174 to losartan in elderly and senile patients was 1.84±0.15, in healthy young volunteers - 3.28±0.77. A statistically significant metabolic E-3174/losartan ratio decrease in elderly and senile patients was demonstrated, which indicates about the decreased activity of CYP2C9 in that age group.