Valproate‐induced Hyperammonemic Encephalopathy

Abstract

Valproate induced hyperammonemic encephalopathy (VHE) is a severe adverse effect of medicine. An epileptic patient with an acute hyperammonemia after the addition of valproic acid to his treatment presented with acute mental status changes consistent with encephalopathy. Notably, plasma ammonia level was 2 times of the upper limit, despite normal liver function tests. Plasma valproic acid level was in the therapeutic range. His symptoms resolved with the discontinuation of valproic acid and Lcarnitine administration. We discuss this case and review the possible mechanisms of valproic acid-associated encephalopathy and the efficacy of L-carnitine.