Enhancement of Solubility with Formulation & in-vitro Evaluation of Oral Nateglinide Compacts by Liquisolid Technique

Abstract

A Liquisolid system is the one of the novel technique to enhance the dissolution rate of poorly water soluble drug such as Nateglinide. In this technique liquisolid system refers to formulation of formed by water insoluble drug mix with non-volatile solvent which is further converted into free flowing, non adherent powder form and which is directly compressed into tablets. In that the propylene glycol is used as non-volatile solvent in which drug having high solubility, microcrystalline cellulose and aerosil (silica) acts as carrier and coating material in the ratio of 10:1 and 20:1 respectively. Sodium starch glycolate acts as superdisintegrants and magnesium stearate as glidant in liquisolid system. The prepared liquisolid system were evaluated to their flowing properties such as bulk density, tap density, Hausner's ratio, Carr's index, and angle of repose. Fourier Transform Infrared spectroscopy (FTIR) and X Ray Diffraction (XRD) study show no interaction between the drug and excipients. Further tablets were evaluated hardness, diameter, thickness, weight variation, friability, disintegration test, uniformity of contents and in-vitro release study show liquisolid compact exhibited higher percentage of drug release than conventional and marketed tablets because of due to increase in wetting properties and surface availability for dissolution