Water-Soluble, Monodisperse, Lanthanide-Doped Y(Gd)VO4 Nanocrystals as Promising Multimodal Bioprobe

Abstract

Monodisperse and water-soluble lanthanide (Ln3+)-doped Y(Gd)VO4 nanocrystals (NCs) have been successfully synthesized by a fast, facile, and environmentally friendly microwave-assisted route with poly(acrylic acid) as the surfactant. The Y(Gd)VO4:5%Ln3+ (Ln = Eu, Dy, Sm) NCs have unique fluorescence properties and polydimethylsiloxane (PDMS)-based white solid nanocomposites containing YVO4:5%Eu3+ NCs show red emission upon UV irradiation. GdVO4 NCs can act as CT and MRI contrast agents as a result of their magnetic and X-ray absorption properties. A layer of SiO2 was coated onto the surfaces of the nanoparticles and MTT assays were carried out to test the cytotoxicity of the YVO4@SiO2 and GdVO4 NCs. The results indicate that the Y(Gd)VO4 NCs have potential in multimodal optical/MRI/CT bio-imaging.