In vitro activities of anidulafungin and other antifungal agents against biofilms formed by clinical isolates of different Candida and Aspergillus species

Abstract

We tested the activities of anidulafungin and other antifungal agents against clinical isolates of different fungal species. For Candida species, high sessile MIC 90s (SMIC 90s) were obtained for fluconazole, voriconazole, and amphotericin B, whereas the anidulafungin SMIC 90s were very low, as were those for caspofungin. Comparatively, for Aspergillus species, higher SMIC 90 values were obtained not only for amphotericin B and voriconazole but also for the echinocandins. Copyright © 2011, American Society for Microbiology. All Rights Reserved.