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From racemic alcohols to enantiopure amines: Ru-catalyzed diastereoselective amination

Journal of the American Chemical Society (2014) 136(36) 12548-12551
DOI: 10.1021/ja5058482
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Abstract

A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellmans chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of α-chiral tert-butanesulfinylamines occurs in yields ranging from 31% to 89% with most examples giving >95:5 dr.

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APA

Oldenhuis, N. J., Dong, V. M., & Guan, Z. (2014). From racemic alcohols to enantiopure amines: Ru-catalyzed diastereoselective amination. Journal of the American Chemical Society, 136(36), 12548–12551. https://doi.org/10.1021/ja5058482

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