Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producerStreptomyces calvus

Abstract

The isolation of three adenosine based metabolites6-8fromStreptomyces calvusis reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin1and two recently identified glycosylated fluoroadenosines2and3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts.