Novel photosensitizer based on bacteriopurpurinimide and magnetite nanoparticles

Abstract

A method of O-propyloxime-N-propoxybacteriopurpurinimide (dipropoxy-BPI) immobilization on magnetite nanoparticles was developed, which allows to overcome the photosensitizer aggregation, maintain high fluorescence of nanoparticles with loaded PS, and give to the latter the ability to dissolve in water. Biological tests on two lines of prostate cancer cells showed that the dipropoxy-BPI intracellular accumulation efficiency depends on tumor cells type and PS dosage forms.