The efficacy and safety of oxycodone in treating the uterine contraction pain after negative pressure aspiration: A randomized, compared, multicenter clinical study

Abstract

This study aims to evaluate the efficacy and safety of oxycodone hydrochloride in treating postoperative uterine contraction pain in dysmenorrhea patients undergoing negative pressure aspiration. This study is a multicenter randomized controlled clinical trial. Two hundred patients with history of moderate or severe dysmenorrhea for negative pressure aspiration were divided into 4 groups evenly (n = 50): the control group (group P, isotonic saline), the low-dose oxycodone group (group O1), the medium-dose oxycodone group (group O2), and the high-dose oxycodone group (group O3). All the 4 groups were followed by slow (45-60 seconds) static push of propofol until eyelash reflex disappeared (a maximum dose of 2.5 mg/kg). Additional propofol (0.6-1 mg/kg) was added if body movement occurred during operation. The postoperative VAS scores in different groups showed that there was no statistical difference between groups P and O1, while there were statistical differences when groups O2 and O3 were compared with group P (P