How to treat hypercholesterolaemia

Abstract

An elevated low density lipoprotein cholesterol is a major cause of atherosclerosis. Reducing the concentration of this lipoprotein stabilises atherosclerotic plaques, and may lead to regression of the atherosclerosis. A moderate reduction of the plasma concentration of this lipoprotein significantly decreases recurrent coronary events. Therapy is a combination of lifestyle modification, nutraceuticals and drug treatment. The most convenient and effective drugs are the HMGCoA reductase inhibitors or 'statins'. They control hyperlipidaemia and help to prevent myocardial infarction, unstable angina, sudden death and stroke.