Inflammatory markers, TBARS and vitamin e in class II and III obese patients before undergoing bariatric surgery

Abstract

Background: Obesity and its comorbidities such as insulin resistance, endothelial dysfunction, hypertension, type 2 diabetes and atherosclerosis have been associated with chronic inflammation and oxidative stress. Weight loss with maintenance is not always possible. Bariatric surgery has been proved to be the only efficient method for weight reduction in patients with clinically severe obesity. It leads to significant weight loss and improvement and/or remission of comorbidities. On the other hand, considering that surgical intervention per se induces oxidative stress and inflammatory response, the objective of the present study was to verify if some inflammatory marker, TBARS and/or Vitamin E could be evaluated before gastric surgery and the relationship with clinical characteristics of the obesity. Methods: a quantitative cross-sectional study was carried out at Clinica Ana Rosa (Santo Andre, SP, Brazil). 100 obese patients (BMI ≥ 35-40 kg/m 2) awaiting bariatric surgery were selected for this study. The control group included 29 individuals, BMI < 35 kg/m 2, with or without associated comorbidities. The patients completed a structured interview. Weight, height, waist and hip circumferences were also collected. Blood was collected. Glucose (G), total cholesterol (TC), HDL cholesterol (HDLc), LDL cholesterol (LDLc), VLDL cholesterol (VLDLc), triglycerides (TG), high-sensitivity C-reactive protein (hs-CRP), vitamin E (VIT E), fibrinogen (FIB), IL-6 (human interleukin-6), TNF-alpha and thiobarbituric acid reactive substances (TBARS) were measured. Results: patients have shown increased serum levels of hs-CRP and FIB. In this study, class II and III obese patients awaiting bariatric surgery and the control group had lower than normal VIT E levels and no significant changes in TBARS levels were observed. Conclusions: Of all markers evaluated hs-PCR and fibrinogen were found altered in obesity group patients. Therefore, our results reinforce the importance of evaluating inflammatory markers in obese patients before bariatric surgery.