Effectiveness of Telemedicine on Wound-Related and Patient-Reported Outcomes in Patients With Chronic Wounds: Systematic Review and Meta-Analysis

Abstract

Background: Telemedicine may provide new vitality and opportunities to the field of wound care and has been advocated as being a potential and feasible strategy for chronic wound management. Objective: This systematic review and meta-analysis aimed to assess the effectiveness of telemedicine on wound-related outcomes and patient-reported outcomes in patients with chronic wounds. Methods: A comprehensive search of 9 databases, including PubMed, Embase, PsycINFO, the Cochrane Library, CINAHL, Web of Science, the China National Knowledge Infrastructure database, the Wanfang database, and the VIP database, was performed to identify eligible randomized controlled trials that investigated the effectiveness of telemedicine for patients with chronic wounds. The primary outcome was wound healing, including healing score, healing time, and healing rate. The quality of the included studies was examined via the Cochrane risk-of-bias tool. Data synthesis was conducted via Review Manager (version 5.4; the Cochrane Collaboration). Due to anticipated heterogeneity, a random-effects meta-analysis was used. Effect estimates are presented as risk ratio (RR) or standard mean differences (SMDs) with 95% CI. The quality of the evidence was assessed via the Grading of Recommendations, Assessment, Development, and Evaluation approach. Results: A total of 22 randomized controlled trials involving 2397 participants met the inclusion criteria. This review demonstrated that telemedicine significantly improved the healing score (SMD −1.46, 95% CI −2.27 to −0.66; P