Role of Atrial Natriuretic Peptide in Experimental Renal Failure

Abstract

VARIOUS aspects of atrial natriuretic peptides (ANP) have been studied since its reports by de Bold.1,2 Although ANP is known to play an important role in the volume regulation of body fluid by displaying natriuresis probably due to vasodilating mechanism, its significance in renal failure has not been clarified. The present study was carried out in order to clarify the renal physiological and systemic hemodynamic effect of exogenous ANP in animal models with deteriorated renal function. In addition, the site of action of ANP was also evaluated in the kidney. © 1988, The Japanese Circulation Society. All rights reserved.