Lignans from the whole plants of hedyotis uncinella

Abstract

Two new lignans, named (7R, 8S)-balanophonin (1) and (7R, 8S)-tomentosanan A (2), together with eight known lignans, burselignan (3), (?)-isolariciresinol (4), (?)-lyoniresinol (5), 5-methoxy-(?)-isolariciresinol (6), (?)-syringaresinol (7), (?)-epipinoresinol (8), (?)-(7'S, 8S, 8'R)-4,4'-dihydroxy-3, 3', 5, 5'-tetramethoxy-7', 9-epoxy-lignan-9'-ol-7-one (9), and (?)-(7R, 8S)-dihydrodehydrodiconiferyl alcohol (10) were isolated from the whole plants of Hedyotis uncinella Hook. et Arn. Structures of these compounds were elucidated through 1H NMR, 13C NMR, 2D NMR, ESI-MS and CD data.