A Novel Magnetoelastic Immunosensor for Ultrasensitively Detecting Carcinoembryonic Antigen

Abstract

A novel wireless immunosensor is developed for the ultra-sensitive detection of carcinoembryonic antigen. The optimum dimension of the microchips, as magnetoelastic sensitive units, was evaluated by simulation and experiments. The unique effects signal amplification and biocompatibility of gold particles contribute to the stability and sensitivity of the sensor. Furthermore, to enhance sensitivity, the working concentrations of antibody and BSA are selected to be 50 mg/mL and 0.1%, respectively. Atom force microscope imaging sheds light on the biological analysis. The Nano-magnetoelastic immunosensor exhibits a linear response to the logarithm of carcinoembryonic antigen (CEA) concentrations ranging from 0.1 to 100 ng/mL, with a detection limit of 2.5 pg/mL. The designed biosensor has merits of excellent stability and sensitivity towards CEA.