Anti-Diabetic Activity of Methanolic Extract of Grape Seeds in Alloxan Induced Diabetic Rats

Abstract

The present study was done to evaluate the anti-diabetic activity of methenolic extract of Grape Seeds (MEGS) in Alloxan induced diabetic rats. Diabetes was induced in Albino rats by administration of single doses of Alloxan monohydrate (120mg/kg, I.P.).The (MEGS) at a dose of 50mg/kg orally was administered as single dose per day to diabetes induced rats for period of 21 days. Acute toxity studies revealed the nontoxic nature of (MEGS), there were no lethality or toxic reactions found at any of the doses selected until the end of the study period. The effect of (MEGS) on blood glucose, serum lipid profile (Cholesterol, triglycerides, Phospholipids, very-low density lipoprotein (VLDL), Low-density lipoprotein (LDL), and high-density lipoprotein (HDL)), serum enzymes (serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), alkaline phosphatases (ALP)), total protein were measured in the diabetic rats. The MEMM showed significant (p<0.01) reduction of blood glucose, lipid profile except HDL, and serum enzymes activity but significantly (p<0.01) increasedTotal protein in diabetic rats.