Cytotoxic petrosiacetylenes from the marine sponge Petrosia sp.

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Abstract

A novel petrosiacetylene analog (petrosiacetylene E) has been isolated from the Korean marine sponge Petrosia sp., along with petrosiacetylene A, B and C. Their structures were elucidated on the basis of spectroscopic methods and the stereochemistry of the new compound was determined by using the modified Mosher's method. Petrosiacetylene E showed higher cytotoxicity against five human cancer cell lines than petrosiacetylene A and B, presumably due to the additional hydroxy group located at C-16. © 2012 AOCS.

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Lee, Y. J., Yoo, S. J., Kang, J. S., Yun, J., Shin, H. J., Lee, J. S., & Lee, H. S. (2013). Cytotoxic petrosiacetylenes from the marine sponge Petrosia sp. Lipids, 48(1), 87–91. https://doi.org/10.1007/s11745-012-3727-5

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