The use of nitroglycerin to control severe hypertension of pregnancy during cesarean section

Abstract

We have used nitroglycerin in six severely hypertensive mothers during general anesthesia for cesarean section. The cases are well represented by the case presented here, with nitroglycerin rapidly providing control of hypertension and blunting the response to endotracheal intubation. In the patient, the short duration of effect allowed rapid adjustment of blood pressure during a period of hemorrhage. Neither neonatal depression nor hypotension has been apparent. It is concluded that in comparison with other antihypertensive agents, nitroglycerin may be a good agent for controlling severe hypertension of pregnancy during general anesthesia for cesarean section. However, the effects of nitroglycerin on uterine blood flow, uterine tone, and fetal acid-base status are unknown and warrant investigation.