Platelet-rich fibrin vs. connective tissue grafts for root coverage in adjacent gingival recessions: a systematic review

Abstract

Background. Gingival recession is a common periodontal condition causing aesthetic issues, dental hypersensitivity, and cervical abrasion. Treatment involves periodontal plastic surgery with connective tissue grafts, LPRF. Aim. This systematic review and meta-analysis aimed to compare L-PRF with CTG in treating GR. Methods and materials. A systematic search of electronic databases found that randomized controlled trials (RCTs) involving patients with Miller class I or II gingival recessions treated with L-PRF and periodontal plastic surgery tech-niques compared to using CTG in combination with periodontal plastic surgery showed a primary gain in clinical attachment level. Statistical analysis used. The analysis of the dichotomous data involved calculating the risk ratio (RR) and 95% confi-dence interval (CI), whereas the continuous data was studied by calculating the mean difference (MD) and 95% CI. The I-squared (I2) statistic assessed the heterogeneity. The Egger's regression test was employed to evaluate the presence of publication bias. Results and conclusions. This meta-analysis of fourteen RCTs found no significant difference in CAL gain 6 months post-operatively between L-PRF and CTG. However, CTG was favored in increasing keratinized mucosa width and achieving more relative root coverage compared to L-PRF. There was no significant difference in gingival recession depth change between the two treatments. Both L-PRF and CTG are effective in treating gingival recession, but CTG may provide better improvements in KMW and rRC.