The PSO4 protein complex associates with replication protein a (RPA) and modulates the activation of ataxia telangiectasia-mutated and RAD3-related (ATR)

Abstract

Background: The function of the PSO4 complex in response to DNA damage remains unclear. Results: The PSO4 complex is required for efficient accumulation of ATRIP at DNA damage sites and the subsequent CHK1 activation and RPA2 phosphorylation. Conclusion: The PSO4 complex modulates ATR activation through interaction with RPA. Significance: We reveal a role for RNA processing factor PSO4 in ATR activation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.