Kanchanamycins, new polyol macrolide antibiotics produced by Streptomyces olivaceus Tu 4018. II. Structure elucidation

Abstract

Kanchanamycins are a new group of polyol macrolide antibiotics isolated from Streptomyces olivaceus Tu 4018. They all share a common bicyclic carbon skeleton formed by a 36-membered lactone ring and a 6-membered hemiacetal ring. A feature unusual for that class of macrolides is the terminal urea moiety observed in kanchanamycin A. The structures of the kanchanamycins were determined by electrospray MS and modern 2D NMR techniques. Due to substantial overlap of the signals intensive use of inverse detected heteronuclear correlation experiments (HSQC, HMBC, 2D-HSQC-TOCSY) was made.