Uso do 5-Fluorouracil associado à cirurgia como terapêutica para o carcinoma de células escamosas em cães

Abstract

The squamous cell carcinoma is a malignant neoplasm of epidermal origin. The 5-fluorouracil is an anticancer agent commonly administered by parenteral route, and its topical use in humans is also described. This paper reports two cases of squamous cell carcinoma in dogs that presented ventral nodes in the abdominal region. In both cases the animals were submitted to neoadjuvant antineoplastic chemotherapy with 5-fluorouracil to reduce the size of the nodules and then to surgery for the excision of the tumors. In one of the dogs, it was used a local 5-Fluorouracil and the other one was administrated intravenously. In both cases, partial remission of the tumors were observed, permitting surgery with larger margin of security. This study demonstrates that the use of 5-fluorouracil in dogs is safe and should be considered in cases of advanced tumors, in which immediate surgery is not possible.