Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness in treatment-resistant cases as well as its epigenetic effects it may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease.
CITATION STYLE
Wilkowska, A., & Cubała, W. J. (2019). Clozapine as transformative treatment in bipolar patients. Neuropsychiatric Disease and Treatment, 15, 2901–2905. https://doi.org/10.2147/NDT.S227196
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