Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field

Abstract

Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.