Histamine H1 receptors are down-regulated as one step in receptor desensitization. Five phosphorylation sites of the H1 receptor seem to play a key role in receptor down-regulation. In contrast, an increase in the H1 receptor expression level following its mRNA elevation was found in the nasal mucosa in hypersensitivity model rats. Up-regulation of the H1 receptor was induced by the direct stimulation of the H1 receptor. H1 receptor up-regulation was suppressed by pretreatment with antiallergic agents. © 2007 The Pharmaceutical Society of Japan.
CITATION STYLE
Fukui, H. (2007, January). Role of therapeutics for allergic diseases in targeting histamine H 1 receptor gene expression. Yakugaku Zasshi. https://doi.org/10.1248/yakushi.127.15
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