Serum uric acid is associated with lumbar spine bone mineral density in healthy Chinese males older than 50 years

Abstract

Objectives: We aimed to investigate the association of serum uric acid (UA) levels with bone mineral density (BMD) at all skeletal sites in healthy Chinese males > 50 years of age. Methods: A cross-sectional study of 385 Chinese males > 50 years of age who underwent health checkup in Huadong Hospital Affiliated to Fudan University in Shanghai, China, was conducted. Clinical and bone characteristics were compared in different UA tertiles (UA1: UA < 4.7 mg/dL, UA2: 4.7 mg/dL ≤ UA < 6 mg/dL and UA3: UA ≥6 mg/dL). Pearson correlation and multiple regression analysis were used to study the correlation of UA with BMD at various skeletal sites. Results: Serum UA levels were positively associated with higher BMD and T-values at the lumbar spine, but not at other skeletal sites, after adjusting for multiple confounding factors. Lumbar spine BMD; the T- and Z-values at the lumbar spine, total hip and femoral neck; as well as intact parathyroid hormone (iPTH) levels are higher in the highest tertile of UA than in the second tertile of UA. Conclusion: Our results provide epidemiological evidence in Chinese Han males aged > 50 years that serum UA levels are positively correlated with lumbar spine BMD and T-values, suggesting that UA may exert protective effect on bone density at the lumbar spine in Chinese males > 50 years of age.