Cytotoxic Test of N-Hexane Extract of Breadfruit Leaves (Artocarpus altilis (Parkinson's ex F.A. Zorn) Fosberg) by Brine Shrimp Lethality Test Method

Abstract

Breadfruit plant (Artocarpus altilis (Parkinson ex F.A Zorn) Fosberg) is a plant that is widely used and has economic value and has a high nutritional content. Breadfruit leaves contain many antioxidants such as flavonoids, xanthones, triterpenoids. Cytotoxic is a medicinal compound that can kill and inhibit the growth of developing cells. This researchaims to determine the value and cytotoxic activity of n-hexane extract of breadfruit leaves LC50 Artocarpus altilis (Parkinson ex F.A Zorn) Fosberg) by the Brine Shrimp Lethality Test (BSLT) method. The results of n-hexane extract of breadfruit leaves have cytotoxic activity with a value of 5.7557 μg / ml with a highly toxic category. Phytochemical screening showed n-hexane extracts of breadfruit leaves contained alkaloids, flavonoids, and steroids. This research can be concluded that breadfruit leavesLC50 (Artocarpus altilis (Parkinson ex F.A Zorn) Fosberg) have the potential to produce cytotoxic compounds.