Highly regioselective Heck-Mizoroki reaction catalyzed by Pd/phosphine ligand in DMSO/[bmim][BF4] under microwave irradiation

Abstract

This work established that highly regioselective Heck-Mizoroki arylation of olefins can be accomplished with aryl halides using Pd2(dba) 3 (dba = dibenzylideneacetone) with phosphine ligand L [L = methyl 4,6-O-benzylidene-3-deoxy-3-(diphenylphosphino)-α-D-altropyranoside] as catalyst in DMSO/[bmim][BF4] under microwave irradiation. In addition, the use of microwave irradiation greatly reduces the reaction time (from hours to minutes), allows low catalyst loading (0.01 mol%) and affords nearly quantitative product yields. © ARKAT-USA, Inc.