Plant-derived antivirals against hepatitis c virus infection

29Citations
Citations of this article
99Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of HCV infection; however, a number of drugs are available for the treatment of infection. The availability of direct-acting antivirals (DAAs) has dramatically improved therapeutic options for HCV genotype 1. However, the high costs and potential for development of resistance presented by existing treatment demonstrate the need for the development of more efficient new antivirals, or combination of therapies that target different stages of the viral lifecycle. Over the past decades, there has been substantial study of compounds extracted from plants that have activity against a range of microorganisms that cause human diseases. An extensive variety of natural compounds has demonstrated antiviral action worldwide, including anti-HCV activity. In this context, plant-derived compounds can provide an alternative approach to new antivirals. In this review, we aim to summarize the most promising plant-derived compounds described to have antiviral activity against HCV.

Cite

CITATION STYLE

APA

Jardim, A. C. G., Shimizu, J. F., Rahal, P., & Harris, M. (2018, February 13). Plant-derived antivirals against hepatitis c virus infection. Virology Journal. BioMed Central Ltd. https://doi.org/10.1186/s12985-018-0945-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free