Survivin and insulin-like growth factor-I: potential role in the pathogenesis of acne and post-acne scar

Abstract

Lay SummaryWe selected 30 patients with acne and post acne scar versus age and sex matched 30 controls to evaluate role of survivin and IGF-1 in reflecting severity of disease and liability for post acne scar, so in those patients early treatment should started. We found that higher statistical significant levels of survivin and IGF-1 in patients than control and positive correlation between survivin with severity of acne. We also found that Patients with high BMI have more severe acne and post acne scar, so decreasing BMI is a vital step in ttt of acne Local use of potential Survivin and IGF1 antagonists in treatment of acne and post acne scar