Synthesis, Characterization and Anticonvulsant Activity of Novel Fused 1,2,4-Triazolo-1,3,4-Thiadiazoles

Abstract

A novel category of 1,2,4-triazolo-1,3,4-thiadiazoles were ready by the utilization of 3-amino-4-hydroxybenzoate as the beginning material. Spectral information results were used for the establishing of prepared compounds. Compounds were screened anticonvulsant activity for obtaining better results by MES test and scPTZ methods. The rotarod method was used for neurotoxicity analysis. Majority of the compounds displayed distinguished anticonvulsant impact practically identical to standard drugs (phenytoin and carbamazepine) with slight neurotoxicity.