Endometrial carcinoma with trophoblastic differentiation. An aggressive form of uterine cancer

Abstract

Three cases of poorly differentiated endometrial adenocarcinoma showing trophoblast‐like differentiation are reported. The multinucleated, syncytiotrophoblast‐like cells were strongly positive for β‐human chorionic gonadotropin (β‐HCG) by immunohistochemical study. High levels of β‐HCG were also present in the patients' serum, but dropped significantly after treatment. The patients had an unusually rapid and progressive clinical course with widespread dissemination and death by tumor. Copyright © 1991 American Cancer Society