Formation of the system of anti-stressor reactions as a non-specific basis for health and longevity

Abstract

The proposed editorial article touches upon aspects of fundamental medicine associated with the discovery of systems of nonspecific adaptation reactions in the organism as a whole. It is shown that the key law of the organism's response to the actions of the external and internal environment consists in the dependence between the reaction quality and the quantity (measure, intensity) of an acting factor. Revealed is the historical sequence of events in the development of the general adaptation reaction theory, beginning with the creation of the theoretical basis of pathology, i.e. description of the adaptation syndrome of stress reaction by Hans Selye, up to the intimate-ly associated and logically continued studies and discovery of anti-stress-type reactions, namely, the reactions of training and activation, undertaken by Lyubov Garkavi, Maria Ukolova and Elena Kvakina. The characterization of archetypes of previously unknown, independent separate symptom complexes is given herein. The philosophy of adaptation discrete responses provided by the organism to different actions includes a higher stage of research pro-gress, when it would be possible to understand the unique natural ability of periodic repetition of the adaptation reactions tetrad in a very wide range of action intensities. This is an adaptation software designed by Nature that is strategically important for the organism, includ-ing different levels of reactivity on a scale of absolute magnitude, and this phenomenon, like the D.I. Mendeleev's periodic law, determines the possibility of forming the qualitatively different states at the same level (periods) and generating the states of the same name at different levels of reactivity (rows). The same name reactions of different levels differ in the nuances of their energy, peroxide and morpho-functional status that is important for conducting the controlled non-specific therapy in order to elevate the natural resistance of the organism. Activation therapy is a form of a targeted regulation of protective systems, namely, the nervous, endocrine and immune ones, that relies on laws, principles, programmed modes and biotechnology of accompanying therapy and functional rehabilitation that is all relevant for a new worldview: personalized medicine. This triggering mechanism works not in isolation from the individual processes of the organism's response, but under due consideration of its identified adaptive re-sponse types, as a guideline in the treatment. This fundamental basis significantly improves the promising capabilities in solving such critical problems of medicine as oncology, cardiovascular diseases, aging, as well as pediatric, sports and space medicine. We hope that translation of the activation therapy developments into clinical practice will improve health of many people, without any limitations in space and time.