Toxicity studies of the rhizome Curcuma xanthorrhiza Roxb. and Curcuma zedoaria Roscoe on hematological and male reproduction system of mice (Mus musculus L.)

Abstract

Chronic (90 days) oral toxicity studies on ethanolic extracts of the rhizome Curcuma xanthorrhiza Roxb. and Curcuma zedoaria Roscoe were carried out in mice. The chronic dosage was 150 mg/kg/day as the extract. Hematological and spermatogenic changes in addition to body weight and external morphological were recorded. C. xanthorrhiza treatment had no significant effect on hematological and spermatogenic changes. C. zedoaria-treated animals revealed a significant fall in RBC, Hb level, and spermatozoa quality as compared to the control. The both extracts failed to show changes of external morphological and body weight and hematological.