Cross antigenicities of leptospira interrogans serovar copenhageni shibaura strain for preparing biological products in japan

Abstract

Cross protective antigenicities of Leptospira were studied with 16 antisera to 13 serovars of Leptospira interrogans and a virulent strain “Shibaura (v)”, which is now considered to belong to serovar copenhageni, for challenge. The anti sera of the rabbits highly immunized with various serovar live antigens were ex amined for leptospiricidal activity; cross immunity was recognized only in the same serogroup, Icterohaemorrhagiae. Serovar icterohaemorrhagiae lacks a part of the antigenic components of copen hageni, but the antiserum to the former showed potent leptospiricidal activity to Shibaura (v). Anti-copenhageni immune serum absorbed with the icterohaemor rhagiae antigen did not show any protective activity to Shibaura (v). © 1980, National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee. All rights reserved.