Pt(II), Pd(II) and UO2(II) complexes of N,N′-bis(2- pyridyl)thiourea; Structural, thermal and biological studies

Abstract

Novel complexes of Pt2+, Pd2+ and UO22+ with N,N′-bis(2-pyridyl)thiourea (H2BPT) 1 were synthesized. These complexes namely [Pt(HBPT)2] 2, [Pd(HBPT) 2] 3 and [UO2(HBPT)(OAc)(H2O)] 4 , were characterized by elemental analysis and spectral measurements. Suggested structures (square-planar for both 2 and 3 complexes and pentagonal-bipyramidal geometry for 4) were confirmed by applying geometry optimization and conformational analysis. Thermal properties and decomposition kinetics of all compounds are investigated. The interpretation, mathematical analysis and evaluation of kinetic parameters (E, A, ΔH, ΔS and ΔG) of all thermal decomposition stages have been evaluated using Coats-Redfern, Horowitz-Metzger and MKN Methods: The biochemical studies showed that, complex 2 has powerful and complete degradation effect on DNA. The antibacterial screening demonstrated that, complex 2 has the maximum and broad range activities against Gram-positive and Gram-negative bacterial strains. © 2011 Elsevier B.V. All rights reserved.