Is aerosolized pentamidine for pneumocystis pneumonia prophylaxis in renal transplant recipients not as safe as we might think?

Abstract

Outbreaks of Pneumocystis pneumonia have been described in renal transplant recipients. Aerosolized pentamidine is frequently used for prophylaxis in this setting. We report our experience with aerosolized pentamidine use in 56 renal transplant recipients. We found high rates of adverse reactions in patients with chronic respiratory disease.