In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase

Abstract

Six potential bispyridinium (E)-but-2-ene linked AChE reactivators were tested on tabun-inhibited acetylcholinesterase in vitro. Their reactivation efficacy was compared to currently available AChE reactivators used in the case of organophosphorus intoxications - pralidoxime, HI-6 and obidoxime. According to the results obtained, (E)-1,4′-bis(4-hydroxyiminomethylpyridinium)but-2-ene dibromide (K075) seems to be the most potent reactivator of tabun - inhibited AChE. From the data, the reactivation potency of these compounds depends on structural factors such as the constitution of the linking chain between both pyridinium rings and the position of the oxime moiety at the pyridinium rings.