Bio-supramolecular photochirogenesis with molecular chaperone: Enantiodifferentiating photocyclodimerization of 2-anthracenecarboxylate mediated by prefoldin

Abstract

Photocyclodimerization of 2-anthracenecarboxylate mediated by molecular chaperone protein was performed for the first time to afford chiral syn-head-to-tail and anti-head-to-head dimers (2 and 3) in 10% and 16% enantiomeric excess, respectively, with enhanced yields of sterically and electrostatically less-favored head-to-head dimers (3 and 4). © 2010 The Royal Society of Chemistry and Owner Societies.