Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical Oncology

Abstract

The shift in cancer therapy from broadly cytotoxic agents toward “personalized” treatments that target specific alterations in each patient’s tumor requires diagnostic pathology approaches that are quantitative and biospecimen-friendly. Novel multiplexed antibody-based imaging technologies can measure single-cell expression of over 60 proteins in intact tumor sections and hold promise for clinical oncology.