Synthesis of substituted benzeneseleninic acid and its antineoplastic activity

Abstract

In view of the negative relationship between selenium and cancer, we designed and synthesized eleven substituted benzeneseleninic acids (N(a-k)) The antineoplastic activity of the title compounds was evaluated via the tests of inhibition of acetylcholinesterase, HL-60 and K562 in vitro, and Ehrlich carcinoma in mice. The result showed that the compounds N(a) and N(b) had distinct antineoplastic activity. The life span increase rate of N(b) on mice bearing Ehrlich carcinoma was 20.30% (20 mg/kg), which was higher than the increase rate of sodium selenite (10.65%, 0.5 mg/kg).