Synthesis, Characterization and Evaluation of Anti-tubercular Activity of Ofloxacin Chalcone Conjugates

Abstract

Synthesis and characterization of Ofloxacin Chalcone derivatives were carried out and evaluated for their antitubercular activity. Synthesized Ofloxacin Chalcone derivatives (Compound A to F). These molecules are characterized by analytical methods (TLC), melting point, and Spectroscopic methods (FT-IR, Mass, NMR). The evaluated antitubercular activity of molecules of synthesized compounds and Ciprofloxacin Pyrazinamide, and Streptomycin as standard drugs. concentrations of synthesized derivatives were prepared (0.8, 1.6, 3.12, 6.25, 12.5, 25, 50, 100 µg/ml) by using sterile deionized water as a solvent. Antitubercular Assay was Performed by Mycobacterium tuberculosis using the MABA method. Analyzed MIC values. Compound E showed the best results among 6 Compounds at a very low concentration at 3.12 µg/ml.