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Efficient One-Pot Synthesis of Triazole-Linked Morpholinone Scaffolds by CuAAC in the Presence of 18-Crown-6

SynOpen (2018) 2(4) 298-305
DOI: 10.1055/s-0037-1610399
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Abstract

A range of bis-heterocyclic derivatives based on novel morpholinone and triazole heterocycles was prepared from iodo-morpholinone. The key step in our strategy is a one-pot procedure based upon copper-catalysed alkyne-azide cycloaddition (CuAAC) from iodo-morpholinone.

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Mayooufi, A., Romdhani-Younes, M., & Thibonnet, J. (2018). Efficient One-Pot Synthesis of Triazole-Linked Morpholinone Scaffolds by CuAAC in the Presence of 18-Crown-6. SynOpen, 2(4), 298–305. https://doi.org/10.1055/s-0037-1610399

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