[18F]-Fluorodeoxyglucose Positron Emission Tomography Standardized Uptake Value as a Predictor of Adjuvant Chemotherapy Benefits in Patients With Nasopharyngeal Carcinoma

Abstract

© AlphaMed Press 2015. Background. The role of adjuvant chemotherapy for the Results. The optimal cutoff value was 8.35 for SUV75o/o, with treatment of nasopharyngeal carcinoma (NPC) is controver-112 (64.4%) patients having lower SUV75%and 62 (35.6%) sial, and the identification of adequate predictive factors is havinghigherSUV75o/o.PatientswithlowerSUV75o/ohadsignificantly warranted. Therefore, we aimed to investigate whether the better 5-year overall survival (OS) and distant metastasis-free mean standardized uptake value (SUV) measured on [18F]- survival. Multivariate analysis revealed that tumor stage, SUV75%, fluorodeoxyglucose (FDG) positron emission tomography and adjuvant chemotherapy were significant prognostic (PET) could predict the survival benefits for NPC patients that factors for OS. Patients with higher SUV75% had significantly receive adjuvant chemotherapy. higher 5-year OS rates with adjuvant chemotherapy than Materials and Methods. The data for 174 NPC patients who without adjuvant chemotherapy (84.3% vs. 32.4%, respec-underwent PET/computed tomography before chemoradiatively; p